Superoxide Dismutase and Oxidative Stress in Amyotrophic Lateral Sclerosis
نویسندگان
چکیده
Oxidative stress is defined as the imbalance between reactive species such as free radicals and oxidants and the antioxidant defenses. Free radicals are molecules with one or more unpaired electrons, while oxidants are molecules with a high potential for taking electrons from other molecules. The more recognized reactive species are the reactive oxygen species (ROS), which include oxygen and its reduction products superoxide, hydrogen peroxide and hydroxyl radical, and the reactive nitrogen species (RNS) such as the free radical nitric oxide and its byproducts, including the powerful oxidant peroxynitrite and the sub-product of peroxynitrite decomposition nitrogen dioxide.
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